Dicer-dependent microRNA pathway safeguards regulatory T cell function
نویسندگان
چکیده
منابع مشابه
Dicer-dependent microRNA pathway safeguards regulatory T cell function
Regulatory T (T reg) cells are indispensable for preventing autoimmunity. Incumbent to this role is the ability of T reg cells to exert their suppressor function under inflammatory conditions. We found that T reg cell-mediated tolerance is critically dependent on the Dicer-controlled microRNA (miRNA) pathway. Depletion of miRNA within the T reg cell lineage resulted in fatal autoimmunity indist...
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ژورنال
عنوان ژورنال: The Journal of Cell Biology
سال: 2008
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb1825oia12